美丽芍药化学成分

Chemical Compositions of Paeonia mairei

摘要:

目的: 研究太白山地区美丽芍药Paeonia mairei的化学成分,为其药理研究与作用机制提供依据. 方法: 采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、重结晶等方法分离纯化化合物,并通过化合物的理化性质和波谱分析鉴定其结构. 结果: 从美丽芍药中分离得到8个化合物,分别为β-谷甾醇(1),齐墩果酸(2),常春藤皂苷元(3),胡萝卜苷(4),大黄酚(5),苯甲酸(6),没食子酸(7),没食子酸乙酯(8). 结论: 化合物5为从该属植物中首次分离得到,其余化合物均为首次从该植物中得到.

Abstract:

Objective: To study the chemical constituents of Paeonia mairei in Taibai mountains and to supply material basis for its pharmacological research and therapeutic mechanism. Method: The compounds from P. mairei were isolated and purified by silica gel column chromatography, Sephadex LH-20 column chromatography and recrystallization method, and their structures were elucidated on the basis of their physicochemical properties and spectra analysis. Result: Eight compounds were obtained and identified as β-sitosterol(1), oleanic acid(2), hederagenin(3), daucosterol(4), chrysophanol(5), benzoic acid(6), gallic acid(7), ethyl gallate(8). Conclusion: Compound 5 were obtained from the genus for the first time. The rest of the compounds was isolated from the plant of P. mairei for the first time.