秦岭地区鸡屎藤中的化学成分

Chemical Compositions Isolated from Paederia scandens

摘要:

目的: 研究太白山地区鸡屎藤Paederia scandens全草的化学成分,为其药效成分及作用机制的深入研究奠定基础. 方法: 采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、重结晶等方法分离纯化化合物,并通过化合物的理化性质和波谱分析鉴定其结构. 结果: 从鸡屎藤中分离并鉴定了13个化合物,分别为β-谷甾醇(1),3,7-二羟基-5-豆甾烯(2),熊果酸(3),3-氧代-12-烯-28-乌苏酸(4),齐墩果酸(5),正三十二烷(6),胡萝卜苷(7),蒲公英赛醇(8),水杨酸(9),3-O-乙酰齐墩果酸(10),琥珀酸(11),杜鹃花酸(12),鸡屎藤苷(13). 结论: 化合物 2,4,6,8~10, 12均为首次从该植物中分离得到.

Abstract:

Objective: To investigate the constituents of the whole herb of Paederia scandens in Taibai mountain. Method: The compounds were isolated by silica gel column chromatography, Sephadex LH-20 column chromatography and recrystallization. Their structures were identified by physicochemical properties and spectra analysis. Result: Thirteen compounds were obtained and identified as β-sitosterol (1), stigmast-5-ene-3,7-diol (2), ursolic acid (3), 3-oxours-12-en-28-oic acid (4), oleanolic acid (5), dotriacotane (6), daucosterol (7), taraxerol (8), salicylic acid (9), 3-O-acetyloleanolic acid (10), succinic acid (11), azelaic acid (12), paederoside (13). Conclusion: Compounds 2, 4, 6, 8-10 and 12 were obtained from the Paederia scandens for the first time.