理气清热方空肠注入辅助常规对症支持干预治疗急性胰腺炎

Liqi Qingre Fang by Jejunal Injection in Combination with Conventional Symptomatic and Supportive Intervention in Treating Acute Pancreatitis

摘要:

目的: 探讨理气清热方剂空肠注入辅助常规对症支持干预治疗急性胰腺炎(AP)的疗效. 方法: 80例符合纳入标准的AP患者随机分为两组,每组各40例.对照组给予常规对症支持干预治疗,观察组在对照组治疗的基础上给予理气清热方剂空肠注入辅助治疗.观察比较两组患者临床疗效,相关临床指标及血清炎性因子水平. 结果: 观察组的治疗总有效率为92.5%,明显高于对照组70.0%(P<0.05).与对照组相比,观察组腹痛、呕吐消失时间,发热、黄疸消退时间及血清淀粉酶恢复时间明显缩短(P<0.05).治疗后,观察组血清炎性因子白细胞介素-6(IL-6),IL-8,肿瘤坏死因子-α(TNF-α)和超敏C反应蛋白(Hs-CRP)水平较对照组明显下降(P<0.05). 结论: 理气清热方剂空肠注入辅助常规对症支持干预治疗AP疗效可靠,可以显著提高治疗总有效率,明显改善相关临床指标,并降低炎性因子水平,减轻炎性反应,值得临床上进一步研究及推广.

Abstract:

Objective: To investigate the clinical effect of Liqi Qingre Fang by jejunal injection in combination with conventional symptomatic and supportive intervention in treating acute pancreatitis (AP). Method: Eighty patients with AP accorded with the inclusion criteria were randomly divided into two groups of 40 patients each. The patients in both groups received conventional symptomatic and supportive intervention and the patients in observation group added Liqi Qingre Fang by jejunal injection. The curative efficacy, relevant clinical indices and inflammatory factors were observed and compared. Result: The patients in observation group had a total therapeutic ratio of 92.5%, which was statistically higher than that of 70.0% in the control group (P<0.05). The disappearance time of abdominal pain, vomiting, fever, jaundice and the recovery time of serum amylase in the observation group were shorter than those in control group (P<0.05). After the treatment, inflammatory factors of interleukins (IL) -6, IL-8, tumor necrosis factor alpha(TNF-α) and high-sensitivity C-reactive protein(Hs-CRP) in the observation group were statistically lower than those in the control group (P<0.05). Conclusion: The effect of using Liqi Qingre Fang by jejunal injection in combination with conventional symptomatic and supportive intervention is reliable in treating AP. It could increase the toal therapeutic ratio, improve relevant indices and alleviate inflammatory reaction, which is worthy to be applied widely in clinic.