中药熏洗灌肠结合西药治疗手足口病

Effects of Traditional Chinese Medicine for Fumigating-washing and Enema Combined with Western Medicine in Treating Hand-foot-mouth Disease

摘要:

目的: 观察中药熏洗灌肠结合西药治疗手足口病疗效。方法: 采用随机数字表法将诊断明确的260例手足口病患儿按年龄段随机分成观察组和对照组,各130例。对照组静脉滴注利巴韦林10 mg·kg^-1,1次/d,酌情给予抗生素治疗;观察组在对照组治疗的基础上加用本院协定中药处方进行中药熏洗及灌肠治疗,入院24 h内开始中药熏洗治疗,早晚2次,中药灌肠治疗,1次/d。观察两组临床疗效、不良反应及并发症情况。结果: 观察组总有效率94.62%明显高于对照组85.38%(P<0.05);观察组退热时间、皮疹消退时间及住院天数均短于对照组(P<0.05);观察组不良反应发生率4.62%低于对照组11.54%(P<0.05)。结论: 中药熏洗灌肠结合西药治疗手足口病儿童,易接受、依从性好、药物吸收全、疗程短、显效快,值得临床推广应用。

Abstract:

Objective: To observe the curative effect of traditional Chinese medicine for fumigating -washing and enema combined with western medicine in treating hand-foot-mouth disease. Method: Two hundred and sixty patients with a clear diagnosis of hand-food-mouth disease were randomly divided into the observation group and the control group according to their ages by a random number table of 130 patients each. The patients in the control group received ribavirin intravenous drip (10 mg·kg^-1) once daily and antibiotics when needed. On the basis of the control group, the patients in the observation group began to receive traditional Chinese medicine prescription of fumigating-washing treatment twice daily and enema treatment once daily within the first 24 hours of admission. The clinical efficacy, adverse reaction and complications of the two groups were observed. Result: The total effective rate in the observation group was 94.62%, which was obviously higher than 85.38% of the control group with statistically significant difference (P<0.05). The antifebrile time, erythra regression time and hospital stays in the observation group were shorter than those in the control group with statistically significant difference (P<0.05). Incidence of adverse reactions in the observation group was 4.62%, which was lower than 11.54% in the control group with statistically significant difference (P<0.05). Conclusion: Chinese medicine for fumigating-washing and enema combined with western medicine therapy is easy to accept and good adherence. Moreover, it has good absorption, short treatment course and takes effect quickly in treating hand-foot-mouth disease of children. It is worthy of clinical popularization and application.