补肾益脑方联合左旋多巴胺治疗肝肾不足,痰瘀阻络证帕金森病40例临床分析

Clinical Analysis of Bushen Yinao Decoction Combined Levodopa in Treating 40 Patients with Parkinson's Disease

摘要:

目的: 观察补肾益脑方联合左旋多巴胺治疗肝肾不足,痰瘀阻络证帕金森病(PD)的临床疗效及对氧化应激和炎症反应的影响. 方法: 将80例PD患者采用随机按数字表法分为对照组和观察组各40例.对照组采用复方卡比多巴片和司来吉兰片治疗,观察组在对照组治疗的基础上加用补肾益脑方内服.两组疗程均为6个月.进行治疗前后帕金森病评定量表(UPDRS),帕金森病生活质量量表(PDQ-39),焦虑自评量表(SAS),抑郁自评量表(SDS),中医证候评分,检测治疗前后超氧化物歧化酶(SOD),丙二醛(MDA),白细胞介素-1 β(IL-1 β)和IL-6水平. 结果: 观察组临床疗效总有效率为87.5%,优于对照组的72.5%(P <0.05);治疗后观察组UPDRSⅠ-Ⅳ评分均低于对照组(P <0.01);治疗后观察组PDQ-39SI,中医证候评分,SAS和SDS均低于对照组(P <0.05, P <0.01);治疗后观察组IL-1 β,IL-6和MDA水平低于对照组,SOD水平高于对照组(P <0.01). 结论: 补肾益脑方联合左旋多巴胺能改善PD(肝肾不足,痰瘀阻络证)运动症状和非运动症状,提高患者生活质量,减轻药物副反应,临床疗效优于单纯西药治疗,其作用机制可能通过减轻氧化应激和炎症反应来实现的.

Abstract:

Objective: To observe the curative efficacy of Bushen Yinao decoction combined levodopa in treating Parkinson's disease (PD), and to investigate its influence on oxidative stress and inflammatory response. Method: Eighty patients with PD were randomly divided into the control group (40 cases) and the observation group (40 cases) by a random number table. Patients in the control group received compound carbidopa tablets and selegiline tablets. Based on the treatment of the control group, patients in the observation group added Bushen Yinao decoction. All patients in both two groups received 6 months of treatment. Before and after treatment, scores of unified PD rating scale (UPDRS), PD quality of life scale (PDQ-39), self-rating anxiety scale (SAS), self-rating depression scale (SDS), traditional Chinese medical (TCM) syndrome scores were graded. Levels of superoxide dismutase (SOD), malondialdehyde (MDA), interleukin-1 β (IL-1 β) and interleukin-6 (IL-6) were detected. Result: The total clinical curative rate of in the observation group was 87.5%, which was superior to that of 72.5% in the control group (P <0.05). After treatment, UPDRS Ⅰ-Ⅳ score in the observation group was less than that in the control group (P <0.01). Levels of PDQ-39SI, TCM syndrome score, SAS and SDS in the observation group were inferior to those in the control group (P <0.05, P <0.01). Standards of IL-1 β,IL-6 and MDA in the observation group were lower than those in the control group, while the SOD level was higher than that in the control group (P <0.01). Conclusion: Bushen Yinao decoction combined levodopa could improve motor and non-motor symptoms, enhance patients' quality of life, reduce the side effects of levodopa in treating PD. Its clinical curative effect is superior to using western medicine treatment alone. The mechanism may be related to reducing oxidative stress and inflammation.