抗毒化浊方对EB病毒感染后衣壳抗原IgA抗体和早期抗原-IgA抗体的影响

Influence of Kangdu Huazhuo Decoction on Capsid Antigen IgA and Early Antigen-IgA Antibodies Infected by EB Virus

摘要:

目的: 观察抗毒化浊方对EB病毒(EBV)感染患者,EB病毒衣壳抗原IgA抗体(VCA-IgA)和早期抗原-IgA抗体(EA-IgA)的作用及对机体免疫炎症因子的影响. 方法: 将118例EBV抗体阳性患者随机采用数字表法按1:2比例分为对照组37例和实验组81例.对照组采用抗毒化浊方安慰剂口服,实验组采用抗毒化浊方内服,两组疗程均为12周.检测治疗前后VCA-IgA和EA-IgA水平,检测治疗前后T淋巴细胞亚群和自然杀伤细胞(NK),肿瘤坏死因子-α(TNF-α),白细胞介素-2(IL-2)和白细胞介素(IL-6)水平. 结果: 治疗后实验组VCA-IgA和EA-IgA水平均低于对照组(P <0.01);治疗后实验组VCA-IgA,EA-IgA阴转率分别为44.15%,41.33%,均高于对照组的19.35%,16.66%(P <0.05);治疗后实验组CD3⁺,CD4⁺,CD4⁺/CD8⁺和NK水平均比治疗前上升,并高于对照组(P <0.01);治疗后实验组TNF-α和IL-6水平低于对照组,IL-2高于对照组(P <0.01). 结论: 抗毒化浊方能降低EBV抗体阳性患者的VCA-IgA,EA-IgA水平,促使VCA-IgA,EA-IgA转阴,其机制可能是通过调节细胞因子,提高机体免疫功能来实现的.

Abstract:

Objective: To observe the effect of Kangdu Huazhuo decoction on capsid antigen IgA (VCA-IgA) and early antigen-IgA (EA-IgA) antibodies of patients infected by the EB virus (EBV), and to investigate its influence on inflammatory factor of body immunity. Method: One hundred and eighteen patients with positive EB virus (EBV) antibodies were randomly divided into the control group (37 cases) and the experimental group (81 cases) by a random number table. Patients in the control group received placebo of Kangdu Huazhuo decoction, and patients in the experimental group took Kangdu Huazhuo decoction orally. All patients in both two groups received 12 weeks of treatment. Before and after treatment, levels of VCA-IgA, EA-IgA, T lymphocyte subsets, natural killer cell(NK), tumor necrosis factor-α(TNF-α), interleukin-2 (IL-2) and interleukin-6 (IL-6) were detected. Result: After treatment, levels of VCA-IgA and EA-IgA in the experimental group were lower than those in the control group (P <0.01). Negative rates of VCA-IgA and EA-IgA in the experimental group were 44.15% and 41.33%, respectively, which were higher than those of 19.35% and 16.66% in the control group (P <0.05). Compared with before, levels of CD3⁺, CD4⁺, CD4⁺/CD8⁺and NK increased after treatment, and the results were higher in the experimental group (P <0.01). Levels of TNF-α and IL-6 were lower, level of IL-2 was higher in the experimental group than those in the control group after treatment (P <0.01). Conclusion: Kangdu Huazhuo decoction could reduce the levels of VCA-IgA and EA-IgA of patients with positive EBV antibodies, and promote the negative rate of VCA-IgA and EA-IgA. Its mechanism of action may be related to ameliorating cytokines and improving levels of immune function.