中西医结合治疗女性更年期高血压疗效的Meta分析

Meta-analysis of Integrated Traditional Chinese and Western Medicine in Treating Menopause Hypertension

摘要:

目的: 评价中西医结合治疗与西药治疗女性更年期高血压的临床疗效. 方法: 计算机检索万方数据知识服务平台(1978—2014),超星读秀Medalink(1955—2014),中国生物医学数据库(1985—2014),中国知网数据库(1990—2014),维普维普期刊数据库(1989—2014),PubMed(1966—2014), EMbase(1984—2014), OVID, Springer Linker(1997—2014), Scince Direct(1998—2014).搜集有关中西医结合药物治疗女性更年期高血压的随机对照研究实验的文献.文献的筛选及评价过程由2名研究员共同完成.按照纳入、排除标准,对文献进行筛选.如出现意见分歧,则向循证医学专家咨询最终方案.按照Meta分析方法,用RevMan 5.2软件,对纳入文献进行数据提取及整合,对中西医结合治疗女性更年期高血压的疗效做出系统化的评价. 结果: 最终纳入文献23篇,共纳入1 969例.Meta分析结果显示:中西医结合药物较西药治疗效果更佳:可降低血压[OR=3.83,95%CI(2.74,5.37), P=0.68],改善更年期症状[OR=3.41,95%CI(22.14,5.42), P=0.77],其差异有统计学意义. 结论: 中西医结合治疗可改善女性更年期临床症状,控制血压,效果优于西药.

Abstract:

Objective: The aim of this study was to compare the clinical efficacy of integration of traditional Chinese medicine(TCM) and western medicine, and the western medicine therapy for menopause hypertension. Method: The randomized controlled trials were collected via searching the internet. The literatures were screened according to inclusion and exclusion criteria. All the assignments were performed by two researchers. If there was disagreement between the two researchers, we would ask evidence based medicine expert for advice, to get an optimal result.The database included the ChianInfo(1978—2014), the Superstar database(1955—2014), the CBM(1985—2014), CNKI(1984—2014), VIP(1989—2014), PubMed(1966—2014), EMbase(1984—2014), OVID, Springer Linker(1997—2014)and Science Direct(1998—2014).According to Meta analysis, the RevMan 5.2 software was used to recover and analyze the literatures, and make the assessment of the integration of TCM and western medicine in treating the women with menopause hypertension. Result: In the study, 23 trials were included. The total number of cases is 1969.The Meta analysis results showed that:Compared with western medicine, the integration of TCM and western medicine would lower blood pressure[OR=3.83,95%CI (2.74,5.37), P=0.68], improve the climacteric symptom:[OR=3.41,95%CI(22.14,5.42), P=0.77]. Conclusion: The Integration of traditional Chinese medicine and western medicine could improve the menopause hypertension symptom, lower blood pressure. All the curative effects are better than western medicine.