炎琥宁联合干扰素治疗手足口病疗效评价的Meta分析

Meta-analysis of Yanhuning Injection Combined with Interferon for Treatment of Hand-foot-mouth Disease

摘要:

目的: 系统评价炎琥宁注射液联合干扰素使用治疗手足口病的临床疗效与安全性. 方法: 采用Cochrane系统评价方法,检索Cochrane Library,EMbase,PubMed,CBM,CNKI和Wanfang Data等数据库,查找有关炎琥宁和干扰素治疗手足口病的随机对照试验(RCT),检索时限均从建库至2014年9月;手工检索相关会议文献,文种限中文和英文;由2名评价者按纳入与排除标准独立筛选文献、提取资料和评价质 量后,采用RevMan 5.2软件进行Meta分析. 结果: 共纳入18个RCT,病例共2 080例.Meta分析结果显示:炎琥宁联合干扰素与单用炎琥宁相比,炎琥宁联合干扰素的有效率更高[OR=3.72,95%CI(2.26,6.11), P <0.000 01],患者退热时间[MD=-0.74,95%CI(-1.05,-0.44), P <0.000 01],疱疹消退时间[MD=-1.17,95%CI(-1.39,-0.96), P <0.000 01]以及溃疡消退时间[MD=-0.83,95%CI(-0.90,-0.76), P <0.000 01]比单用炎琥宁治疗时间更短,差异均具有统计学意义.炎琥宁联合干扰素与单用干扰素相比,联合用药在总有效率[OR=3.95,95%CI(2.03,7.69), P <0.00 01],退热时间[MD=-0.60,95%CI(-0.76,-0.45), P <0.000 01],疱疹消退时间[MD=-0.98,95%CI(-1.12,-0.84), P <0.000 01]以及溃疡消退时间[MD=-0.94,95%CI(-1.23,-0.65), P <0.000 01]比单用干扰素更具有优势,其差异具有统计学意义. 结论: 炎琥宁联合干扰素治疗手足口病的疗效优于单用炎琥宁和单用干扰素.

Abstract:

Objective: The study aimed to systematically review the clinical efficacy and safety of Yanhuning combined with interferon for curing the hand-foot-mouth disease (HFMD). Method: Using the Cochrane system evaluation method, the retrieval of the Cochrane Library, EMbase, PubMed, CBM, CNKI and Wanfang Data database, a randomized controlled trial of finding out about the Yanhuning and interferon in the treatment of hand foot and mouth disease (RCT), were searched from inception to 2014 September; manual search of relevant conference literature, language and English Chinese limit; 2 reviewers independently screened according to the inclusion and exclusion criteria, extracted data and literature quality evaluation, Meta-analysis was carried out using RevMan 5.2 software. Result: There were 18 studies (2 080 cases) included. The results of Meta-analysis showed that compared to Yanhuning alone, Yanhuning combined with interferon increased the total treatment efficiency of HFMD [OR=3.72,95%CI(2.26,6.11), P <0.000 01], with shorter cooling time [MD=-0.74,95%CI(-1.05,-0.44), P <0.000 01], simplex regression time[MD=-1.17,95%CI(-1.39,-0.96), P <0.000 01], and healing time[MD=-0.83,95%CI(-0.90,-0.76), P <0.000 01]. Compared to interferon alone, Yanhuning combined with interferon increased the total treatment efficiency of HFMD [OR=3.95,95%CI(2.03,7.69), P <0.000 1], with shorter cooling time[MD=-0.60,95%CI(-0.76,-0.45), P<0.000 01], simplex regression time[MD=-0.98,95%CI(-1.12,-0.84), P <0.000 01], healing time [MD=-0.94,95%CI(-1.23,-0.65), P <0.000 01]. Conclusion: The current study showed that Yanhuning combined with interferon are efficacious in the treatment of HFMD than Yanhuning injection alone or interferon alone.