杜仲及盐杜仲饮片的均匀化分析

Homogenization of Eucommiae Cortex and Salt-processed Product of Eucommiae Cortex Decoction Pieces

摘要:

目的：通过筛选粉碎工艺得到均匀性最佳的杜仲及盐杜仲粉末，以期将其分别作为杜仲、盐杜仲饮片质量评价的标准对照品。方法：依据不同粉碎方式下杜仲、盐杜仲饮片粉末的显微观察和粒径分布，并参考已上市的杜仲对照药材粉末粒径分布，确定超微粉碎为杜仲、盐杜仲饮片的粉碎方式；近红外技术结合色彩色差计、有效成分的HPLC含量测定对杜仲、盐杜仲饮片的光谱差异、外观颜色、内在有效成分含量3个方面进行考察，以比较饮片的均匀性。结果：超微粉碎30 min所得杜仲、盐杜仲饮片粉末较细，流动性较好，其光谱整体偏差分别为0.002和0.001，总色值的RSD分别为0.5%和0.4%，松脂醇二葡萄糖苷含量的RSD均为2.3%。结论：超微粉碎30 min为杜仲、盐杜仲饮片的最佳粉碎工艺，为杜仲、盐杜仲饮片的均匀化技术规范制定提供参考依据。

Abstract:

Objective: To get Eucommiae Cortex and salt-processed product of Eucommiae Cortex decoction pieces powder with optimum homogeneity by screening crushing process,in order to make them to be the standard reference materials. Method: According to microexamination and particle size distribution of Eucommiae Cortex and salt-processed product of Eucommiae Cortex decoction pieces in different grinding manners and the particle size distribution of control medicinal powder,ultrafine grinding was optimum grinding manner of them.Homogeneity of decoction pieces was compared by means of spectral difference,color and content of active ingredient. Result: Eucommiae Cortex and salt-processed product of Eucommiae Cortex decoction pieces powder was fine and had good fluidity when ultrafine grinding of 30 min,the spectral deviations of them were 0.002 and 0.001,RSDs of total color value were 0.5% and 0.4%,RSDs of pinoresinol diglucoside content of them were 2.3%. Conclusion: Ultrafine grinding of 30 min is the best grinding technology for Eucommiae Cortex and salt-processed product of Eucommiae Cortex decoction pieces,it provides a reference for formulating homogenization specifications of them.