车前子化学成分研究(Ⅱ)

Chemical Constitutes from Plantaginis Semen(Ⅱ)

摘要:

目的：研究车前子（Plantaginis Semen）的化学成分。方法：利用大孔树脂HP-20，正/反相硅胶柱色谱，Sephadex LH-20凝胶和高压制备色谱技术等分离纯化化合物，根据化合物理化性质和波谱数据鉴定化合物结构。结果：从车前子中分离得到9个化合物，分别鉴定为cyclo-（S-Pro-R-Phe，1），（+）-去氢催吐萝芙木醇[（+）-dehydrovomifoliol，2]，blumenol A（3），吲哚-3-甲醛（1H-indole-3-carbaldehyde，4），胡萝卜苷（daucosterol，5），α-亚油酸（α-linoleic acid，6），α-亚麻酸（α-linolenic acid，7），γ-亚麻酸（γ-linolenic acid，8），油酸（oleic acid，9）。结论：化合物1，2，4，8为首次从车前科植物中分离得到。

Abstract:

Objective: To study the chemical constituents of Plantaginis Semen. Method: The constituents were isolated and purified by macroporous resin HP-20, column chromatography over silica gel, RP-8 silica gel, Sephadex LH-20 and by preparative HPLC. Their structures were elucidated by analysis of physical and chemical properties and spectral data. Result: Nine compounds were isolated from Plantaginis Semen and their structures were identified as cyclo-(S-Pro-R-Phe) (1), (+)-dehydrovomifoliol (2), blumenol A (3), 1H-indole-3-carbaldehyde (4), daucosterol (5), α-linoleic acid (6), α-linolenic acid (7), γ-linolenic acid (8), oleic acid (9). Conclusion: Compounds 1, 2, 4, 8 were isolated from Plantaginaceae for the first time.