吴茱萸汤颗粒剂、配方颗粒剂及传统汤剂中指标成分的含量比较

Comparison of Contents of Index Components in Granule,Dispensing Granule and Traditional Decoction of Wuzhuyu Tang

摘要:

目的：比较吴茱萸汤颗粒剂、配方颗粒剂与传统汤剂中指标性成分的含量差异。方法：采用不同高效液相色谱法（HPLC）测定吴茱萸颗粒剂、配方颗粒剂与传统汤剂中吴茱萸碱、吴茱萸次碱、人参皂苷Re和人参皂苷Rb₁的含量，并对含量测定方法进行考察。结果：颗粒剂、配方颗粒剂与传统汤剂中吴茱萸碱和吴茱萸次碱质量浓度之和分别为47.32，13.49，12.60 mg·L^-1，颗粒剂、配方颗粒剂中二者的质量浓度之和分别为传统汤剂的3.76，1.07倍；人参皂苷Re和人参皂苷Rb₁质量浓度之和分别为335.23，345.28，307.39 mg·L^-1。颗粒剂、配方颗粒剂中二者的质量浓度之和分别为传统汤剂的1.09，1.12倍。结论：比较吴茱萸碱和吴茱萸次碱的含量时，颗粒剂与传统汤剂相差较大，而配方颗粒剂与传统汤剂基本一致；比较人参皂苷Re和人参皂苷Rb₁的含量时，颗粒剂、配方颗粒剂与传统汤剂基本一致。

Abstract:

Objective: To compare the contents of index components in granule,dispensing granule and traditional decoction of Wuzhuyu Tang. Method: The contents of evodiamine,rutaecarpine,ginsenoside Re and ginsenoside Rb₁ in these three forms of Wuzhuyu Tang were determined by HPLC. Result: The total contents of evodiamine and rutaecarpine in granule,dispensing granule and traditional decoction of Wuzhuyu Tang were 47.32,13.49,12.60 mg·L^-1,the total contents of ginsenoside Re and ginsenoside Rb₁ in these three forms of Wuzhuyu Tang were 335.23,345.28,307.39 mg·L^-1. Conclusion: The granule is obviously different from the traditional decoction in terms of the content of evodiamine and rutaecarpine,while other index component are basically identical.