肝豆灵片联合二巯丙磺酸钠对痰瘀互结型肝豆状核变性患者血清丙二醇、超氧化物歧化酶的影响

Effect of Gandouling Tablet Combined with Sodium Dimercaptopropane Sulfonate on Propylene Glycol and Superoxide Dismutase Levels in Serum of Patients with Phlegm and Blood Stasis Type Wilson's Disease

摘要:

目的：观察肝豆灵联合二巯丙磺酸钠治疗对痰瘀互结型肝豆状核变性患者血清丙二醇（MDA），超氧化物歧化酶（SOD）的影响，并探讨其作用机制。方法：选取安徽中医药大学第一附属医院脑病科确诊为肝豆状核变性的住院患者120例，随机分为对照组和治疗组，各60例，其中对照组使用二巯丙磺酸钠常规治疗，治疗组在常规治疗的基础上加用肝豆灵片，治疗4个疗程。在治疗前后分别进行血清MDA，SOD，24 h尿铜、神经功能评分等相关指标评估。结果：与治疗前比较，两组治疗后血清MDA含量均减低，SOD活性均增加（P<0.05），治疗组优于对照组（P<0.01）；两组神经功能评分均下降（P<0.05），治疗组疗效优于对照组（P<0.01）；两组治疗后24 h尿铜均有明显改善，其中治疗组改变显著（P<0.01），治疗组驱铜效果优于对照组（P<0.05）；两组肝功能指标均有降低（P<0.05），治疗组显著优于对照组（P<0.01）。两组铜蓝蛋白与铜氧化酶治疗前后变化不大。根据两组不良反应分析，发现治疗组副作用小。结论：中西医结合治疗能明显降低肝豆状核变性患者中血清MDA含量，增加SOD活性，可以加强驱铜效果，改善临床症状，在一定程度上可以延缓病情进展，减轻患者痛苦。且不良反应较少，安全性高，在临床上得到广泛运用。

Abstract:

Objective: To observe the effect of Gandouling tablet combined with Sodium Dimercaptopropane Sulfonate on the levels of propylene glycol and superoxide dismutase in serum of patients with phlegm and blood stasis type Wilson's disease (WD), and investigate its mechanism. Method: The 120 WD patients in The First Affiliated Hospital of Anhui University of Chinese Medicine were randomly divided into control group and treatment group, with 60 cases in each group. Patients in control group received Sodium Dimercaptopropane Sulfonate routine treatment, and patients in treatment group added Gandouling tablets based on the treatment in control group for a total of 4 treatment courses. Before and after treatment, the serum propylene glycol (MDA), superoxide dismutase (SOD), 24 h urine copper and other indicators such as neurological function scores were observed. Result: In the both groups after treatment, MDA content was decreased, SOD activity was increased (P<0.05), and the effect in treatment group was significantly better than that in control group (P<0.05); neurological function scores were decreased in both groups (P<0.05), and the effect in treatment group was significantly better than that in control group (P<0.01); 24 h urine copper was improved in both groups, and the effect in treatment group was more significant (P<0.01); the decoppering effect in treatment group was better than that in control group (P<0.05); liver function indexes were decreased in both groups (P<0.05), and the effect in treatment group was significantly better than that in control group (P<0.01). However, ceruloplasmin and copper oxidase levels did not change much after treatment in both groups. The adverse reactions results showed that there were less side effects in treatment group. Conclusion: The combination of traditional Chinese and Western medicine treatment can significantly reduce the content of serum MDA in WD patients, increase the activity of SOD, strengthen the decoppering effect, improve clinical symptoms, and to a certain extent, it can delay the progress of the disease and relieve pain for the patients. Moreover, it had less adverse reactions with high safety, so it should be widely used in clinical application.