强直性脊柱炎的发病机制及中药干预研究进展

Research Progress on Pathogenesis of Ankylosing Spondylitis and Intervention of Traditional Chinese Medicine： A Review

摘要:

强直性脊柱炎（AS）是一种以慢性腰背痛为主要临床表现的炎症性自身免疫性疾病，主要影响中轴关节，也可累及外周关节和多种器官，严重者出现脊柱强直或畸形，影响患者的生活质量和身体健康。AS发病因素复杂，与遗传、免疫、肠道菌群等相关，发病机制暂未明确。其中，炎症反应、骨破坏和异位骨化为AS的主要病理特征，在AS疾病进程中具有重要作用。中医药具有多靶点、多途径、多成分等药理学作用，可通过抗炎、抑制骨破坏和防治异位骨化防治AS，且临床效果显著，但未见相关文献报道。因此，该综述通过阐述炎症反应、骨破坏和异位骨化与AS发生发展的关系，总结中医药从抗炎、抑制骨破坏和防治异位骨化治疗AS的最新研究报道，旨在为进一步研究中医药在AS防治中提供参考和新的思路与方向。

Abstract:

Ankylosing spondylitis （AS） is an inflammatory autoimmune disease with chronic low back pain as the main clinical manifestation， which mainly affects the axial joints， peripheral joints and various organs. In severe cases， the spine is stiff or deformed， which affects the quality of life and health of patients. The pathogenic factors of AS are complex， which are related to heredity， immunity and intestinal flora. The pathogenesis of AS is not clear yet. Among them， inflammatory reaction， bone destruction and heterotopic ossification are the main pathological features of AS， which play an important role in the disease process of AS. Traditional Chinese medicine has multi-target， multi-channel and multi-component pharmacological effects， which can prevent and treat AS by anti-inflammation， inhibiting bone destruction and preventing heterotopic ossification， and the clinical effect is remarkable， but there is no relevant literature report. Therefore， this review expounds the relationship between inflammatory reaction， bone destruction and heterotopic ossification and the occurrence and development of AS， and summarizes the latest research reports of traditional Chinese medicine in treating AS from anti-inflammatory， inhibiting bone destruction and preventing heterotopic ossification， aiming at providing reference and new ideas and directions for further research on the prevention and treatment of AS by traditional Chinese medicine.