符合中医药特点的中药药效评价创新方法： 基于五脏关联规律的中药复方“同治/同调”药效优势表征体系构建思考

Innovation of Methods for Efficacy Evaluation of Traditional Chinese Medicine Compound Prescriptions： Establishment of Characterization System for Simultaneous Treatment/Regulation Based on Correlation Patterns of Five Zang-organs

摘要:

中药复方临床疗效优势在实验研究中始终无法得以充分表征，成为制约中药药理学乃至中医药发展的瓶颈问题。五脏生克制化理论指导下的“同治/同调”思想，在历代中医临床中有重要指导意义，且仍广泛应用于当代临床。但这一独特而极具临床价值的辨治用药体系，在现代中药药理学研究中被完全忽视，可能是制约中药复方疗效优势药理学表征的关键因素之一。该文在系统总结中药复方药效评价阶段性研究进展和成就基础上，从“藏象”与五脏核心观、基于五脏“生克制化”的中医疾病认识观等方面，思考基于中医五脏关联规律的中药复方“同治/同调”药效优势挖掘路径，并以心肺关系为切入点，以“心肺同治”为范例，思考中药药效优势的药理学表征新方法，以期为中药复方药效评价方法学突破提供新的思路。

Abstract:

The clinical efficacy advantages of traditional Chinese medicine （TCM） compound prescriptions have always been inadequately characterized in experimental research，which has become a bottleneck restricting the development of TCM pharmacology and even the progress of TCM. The concept of simultaneous treatment/regulation，guided by the theory of mutual generation and restriction of five zang-organs，has guiding significance in the clinical practice of TCM throughout history and is still widely used in the current clinical practice. However，this unique and clinically valuable diagnostic and therapeutic medication system based on the syndrome differentiation has been completely ignored in the modern research of TCM pharmacology，which might be one of the key factors restricting the pharmacological characterization of the therapeutic advantages of TCM compound prescriptions. On the basis of systematically summarizing the phased progress and achievements of the efficacy evaluation of TCM compound prescriptions，this article explores the path of exploring the pharmacological advantages of TCM compound prescriptions on simultaneous treatment/regulation on the basis of the correlation patterns of five zang-organs，from the theory of Zangxiang，the core concept of five zang-organs，and the TCM disease recognition based on the theory of mutual generation and restriction of five zang-organs. With the heart-lung correlation as a breakthrough point，this study explored a new characterization method for the pharmacological advantages of TCM，aiming to provide new ideas for evaluating the efficacy of TCM compound prescriptions.